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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10625

Cayman Chemical Item Number 13836

(CAS 137346-42-0)

CAY10625 (CAS 137346-42-0)

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Description

Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/Diablo, caspase-3, and caspase-7.1,2 survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/Diablo, exhibiting an IC50 value of 2.2 µM.3 It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 µM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.3

1 Ryan, B.M., O'Donovan, N., and Duffy, M.J. Survivin: A new target for anti-cancer therapy. Cancer Treat Rev 35 553-562 (2009).

2 Shin, S., Sung, B., Cho, Y.S., et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry 40 1117-1123 (2001).

3 Oikawa, T., Unno, Y., Matsuno, K., et al. Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO. Biochem Biophys Res Commun 393 253-258 (2010).

Formal Name 7-​nitro-​10-​octyl-​3-​phenyl-​pyrimido[4,​5-​b]quinoline-​2,​4(3H,​10H)-​dione
CAS Number 137346-42-0
Molecular Formula C25H26N4O4
Formula Weight 446.5
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1C2=CC3=C(C=CC([N+]​([O-]​)​=O)​=C3)​N(CCCCCCCC)​C2=NC(N1C4=CC=CC=C4)​=O

Background Reading

Oikawa, T., Unno, Y., Matsuno, K., et al. Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO. Biochem Biophys Res Commun 393 253-258 (2010).

Ryan, B.M., O'Donovan, N., and Duffy, M.J. Survivin: A new target for anti-cancer therapy. Cancer Treat Rev 35 553-562 (2009).

Shin, S., Sung, B., Cho, Y.S., et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry 40 1117-1123 (2001).
Size Price Quantity Subtotal
1 mg $66.00 $0.00
5 mg $297.00 $0.00
10 mg $528.00 $0.00
50 mg $2,310.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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