See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

SC-19220

Cayman Chemical Item Number 14060

(CAS 19395-87-0)

SC-19220 (CAS 19395-87-0)

See more

Description

SC-19220 is a dibenzoxazepine which acts as a selective antagonist of prostaglandin E2 (PGE2) at the EP1 receptor.1,2 At doses between 0.3-300 µM, SC-19220 acts as a competitive antagonist of PGE2-induced smooth muscle contractions of guinea pig ileum and stomach.3,4 SC-19220 acts as a PGE2 antagonist in the EP1 receptor mediated contraction of guinea pig trachea.5 SC-19220 displaces radiolabeled PGE2 from the cloned human EP1 receptor with an IC50 of 6.7 µM and exhibits no binding at the human EP2 receptor.6,7 It binds very weakly and shows no selectivity for the mouse EP1 receptor, suggesting species differences between the human and mouse EP1 receptors.8

1 Coleman, R.A., Eglen, R.M., Jones, R.L., et al. Classification of prostanoid receptors IUPHAR receptor compendium. IUPHAR Compendium 1-12 (1997).

2 Zeng, L., An, S., and Goetzl, E.J. Selective regulation of RNK-16 cell matrix metalloproteinases by the EP4 subtype of prostaglandin E2 receptor. Biochemistry 35 7159-7164 (1996).

3 Rakovska, A., and Milenov, K. Antagonistic effect of SC-19220 on the responses of guinea-pig gastric muscles to prostaglandins E1, E2, and F2α. Arch Int Pharmacodyn 268 59-69 (1984).

4 Sanner, J. Prostaglandin Inhibition with a dibenzoxazepine hydrazide derivative and morphine. Ann N Y Acad Sci 180 396-409 (1971).

5 Coleman, R.A., and Kennedy, I. Characterisation of the prostanoid receptors mediating contraction of guinea-pig isolated trachea.. Prostaglandins 29 363-375 (1985).

6 Funk, C.D., Furci, L., Fitzgerald, G.A., et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem 268 26767-26772 (1993).

7 Bastien, L., Sawyer, N., Grygorczyk, R., et al. Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. J Biol Chem 269 11873-11877 (1994).

8 Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122 217-224 (1997).

Formal Name 8-​chloro-​dibenz[b,​f][1,​4]oxazepine-​10(11H)-​carboxy-​(2-​acetyl)hydrazide
CAS Number 19395-87-0
Molecular Formula C16H14ClN3O3
Formula Weight 331.8
Formulation A crystalline solid
Purity >96%
λmax 203 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CC(=O)​NNC(=O)​N1Cc2ccccc2Oc2ccc(Cl)​cc12

Background Reading

Zeng, L., An, S., and Goetzl, E.J. Selective regulation of RNK-16 cell matrix metalloproteinases by the EP4 subtype of prostaglandin E2 receptor. Biochemistry 35 7159-7164 (1996).

Coleman, R.A., Eglen, R.M., Jones, R.L., et al. Classification of prostanoid receptors IUPHAR receptor compendium. IUPHAR Compendium 1-12 (1997).

Rakovska, A., and Milenov, K. Antagonistic effect of SC-19220 on the responses of guinea-pig gastric muscles to prostaglandins E1, E2, and F2α. Arch Int Pharmacodyn 268 59-69 (1984).

Coleman, R.A., and Kennedy, I. Characterisation of the prostanoid receptors mediating contraction of guinea-pig isolated trachea.. Prostaglandins 29 363-375 (1985).

Sanner, J. Prostaglandin Inhibition with a dibenzoxazepine hydrazide derivative and morphine. Ann N Y Acad Sci 180 396-409 (1971).

Show all 5 Hide all but first 3
Size Price Quantity Subtotal
1 mg $15.00 $0.00
5 mg $68.00 $0.00
10 mg $120.00 $0.00
25 mg $263.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

EP1 Receptor Polyclonal Antibody
EP2 Receptor Polyclonal Antibody
EP4 Receptor (N-Term) Polyclonal Antiserum
ONO-8711
Prostaglandin E2
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?