Cayman Chemical | SC-19220 | Description (CAS 19395-87-0)

14060 SC-19220

(CAS 19395-87-0)

Click image to enlarge

• See below for pricing and ordering

• See analysis tools

• See more Prostaglandins; Neuroscience

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

SC-19220 is a dibenzoxazepine which acts as a selective antagonist of prostaglandin E₂ (PGE₂) at the EP₁ receptor.^1,2 At doses between 0.3-300 µM, SC-19220 acts as a competitive antagonist of PGE₂-induced smooth muscle contractions of guinea pig ileum and stomach.^3,4 SC-19220 acts as a PGE₂ antagonist in the EP₁ receptor mediated contraction of guinea pig trachea.⁵ SC-19220 displaces radiolabeled PGE₂ from the cloned human EP₁ receptor with an IC₅₀ of 6.7 µM and exhibits no binding at the human EP₂ receptor.^6,7 It binds very weakly and shows no selectivity for the mouse EP₁ receptor, suggesting species differences between the human and mouse EP₁ receptors.⁸

1 Coleman, R.A., Eglen, R.M., Jones, R.L., et al. Classification of prostanoid receptors IUPHAR receptor compendium. IUPHAR Compendium (1997).

2 Zeng, L., An, S., Goetzl, E.J. Selective regulation of RNK-16 cell matrix metalloproteinases by the EP₄ subtype of prostaglandin E₂ receptor. Biochemistry 35 7159-7164 (1996).

3 Rakovska, A., Milenov, K. Antagonistic effect of SC-19220 on the responses of guinea-pig gastric muscles to prostaglandins E₁, E₂, and F_2α Arch Int Pharmacodyn 268, 59-69 (1984).

4 Sanner, J. Prostaglandin Inhibition with a dibenzoxazepine hydrazide derivative and morphine. Ann N Y Acad Sci 180 396-409 (1971).

5 Coleman, R.A., Kennedy, I. Characterisation of the prostanoid receptors mediating contraction of guinea-pig isolated trachea. Prostaglandins 29 363-375 (1985).

6 Funk, C.D., Furci, L., Fitzgerald, G.A., et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP₁ subtype. J Biol Chem 268 26767-26772 (1993).

7 Bastien, L., Sawyer, N., Grygorczyk, R., et al. Cloning, functional expression, and characterization of the human prostaglandin E₂ receptor EP₂ subtype. J Biol Chem 269 11873-11877 (1994).

8 Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122 217-224 (1997).

	Download Product Insert 129 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 14060 SC-19220

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-15.
Prices are subject to change without notice.

Related Products