14350  8-iso Prostaglandin E2

8-iso PGE2; 8-epi PGE2 (CAS 27415-25-4)

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Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.1 It is a potent renal vasoconstrictor in the rat.1,2 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.3 When infused into the renal artery of the rat at a concentration of 4 µg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.1
1  Morrow, J.D., Minton, T.A., Mukundan, C.R., et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem 269 4317-4326 (1994).
2  Hoffman, S.W., Moore, S., Ellis, E.F. Isoprostanes: Free radical-generated prostaglandins with constrictor effects on cerebral arterioles. Stroke 28 844-84 (1997).
3  Longmire, A.W., Roberts, L.J., Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).


Purchase 14350 8-iso Prostaglandin E2

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Pricing updated 2010-03-13.
Prices are subject to change without notice.

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.

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