Cayman Chemical | 8-iso Prostaglandin E2 | Description • 8-iso PGE2; 8-epi PGE2 (CAS 27415-25-4)

14350 8-iso Prostaglandin E₂

8-iso PGE₂; 8-epi PGE₂ (CAS 27415-25-4)

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• See more Isoprostanes; Prostaglandins; Oxidative Injury

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8-iso PGE₂ is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.¹ It is a potent renal vasoconstrictor in the rat.^1,2 8-iso PGE₂ inhibits U-46619 or I-BOP-induced platelet aggregation with IC₅₀ values of 0.5 and 5 µM, respectively.³ When infused into the renal artery of the rat at a concentration of 4 µg/kg/min, 8-iso PGE₂ decreases the GFR and renal plasma flow by 80% without affecting blood pressure.¹

1 Morrow, J.D., Minton, T.A., Mukundan, C.R., et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem 269 4317-4326 (1994).

2 Hoffman, S.W., Moore, S., Ellis, E.F. Isoprostanes: Free radical-generated prostaglandins with constrictor effects on cerebral arterioles. Stroke 28 844-84 (1997).

3 Longmire, A.W., Roberts, L.J., Morrow, J.D. Actions of the E₂-isoprostane, 8-iso-PGE₂, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).

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Purchase 14350 8-iso Prostaglandin E₂

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Pricing updated 2010-03-13.
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