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8-iso Prostaglandin E₂ isopropyl ester

Cayman Chemical Item Number 14352

8-iso PGE₂ isopropyl ester (CAS 330589-21-4)

8-iso Prostaglandin E2 isopropyl ester (CAS 330589-21-4)

See more	Isoprostanes (34) Prostaglandins (513) Oxidative Injury (258)

Description

8-iso PGE₂ isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE₂. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids.

Synonyms	8-iso PGE2 isopropyl ester
Formal Name	9-oxo-11α,15S-dihydroxy-(8β)-prosta-5Z,13E-dien-1-oic acid, isopropyl ester
CAS Number	330589-21-4
Molecular Formula	C₂₃H₃₈O₅
Formula Weight	394.6
Formulation	A solution in ethanol
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)/C=C/[C@H]1C(O)CC(=O)[C@H]1C/C=C\CCCC(=O)OC(C)C

Background Reading

Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E₂-isoprostane, 8-iso-PGE₂, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).

Morrow, J.D., Minton, T.A., Mukundan, C.R., et al. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes. J Biol Chem 269 4317-4326 (1994).

8-iso Prostaglandin E2 isopropyl ester is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$69.00		$0.00
5 mg	$311.00		$0.00
10 mg	$552.00		$0.00
50 mg	$2,415.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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8-iso Prostaglandin E2 isopropyl ester