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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

8-iso-15-keto Prostaglandin E2

Cayman Chemical Item Number 14390

8-iso-15-keto PGE2

8-iso-15-keto Prostaglandin E2

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Description

8-iso-15-keto Prostaglandin E2 (8-iso-15-keto PGE2) is an isoprostane, one member of a large family of biomarkers produced by the free radical peroxidative degradation of membrane lipids.1 8-iso-15-keto PGE2 is the theoretical first metabolite of 8-iso PGE2 via the 15-hydroxy PGDH pathway. While a number of potent biological activities have been attributed to 8-iso PGE2,2 there are no published reports at this time regarding its metabolism.

1 Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

2 Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).

Synonyms
  • 8-iso-15-keto PGE2
Formal Name 9,​15-​dioxo-​11α-​hydroxy-​(8β)-​prosta-​5Z,​13E-​1-​oic acid
Molecular Formula C20H30O5
Formula Weight 350.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(/C=C/[C@H]​([C@@H]​1C/C=C\CCCC(O)​=O)​[C@H]​(O)​CC1=O)​=O

Background Reading

Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

Longmire, A.W., Roberts, L.J., and Morrow, J.D. Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor. Prostaglandins 48 247-256 (1994).

8-iso-15-keto Prostaglandin E2 is available in the following screening library:

Size Price Quantity Subtotal
100 µg $15.00 $0.00
500 µg $68.00 $0.00
1 mg $120.00 $0.00
5 mg $525.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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