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9-deoxy-9-methylene Prostaglandin E₂

Cayman Chemical Item Number 14410

9-deoxy-9-methylene PGE₂ (CAS 61263-32-9)

9-deoxy-9-methylene Prostaglandin E2 (CAS 61263-32-9)

See more	Prostaglandins (513)

Description

9-deoxy-9-methylene PGE₂ is a stable, isosteric analog of PGE₂. 9-deoxy-9-methylene PGE₂ retains the biological profile of PGE₂ with fewer side effects. In the rat 9-deoxy-9-methylene PGE₂ is equipotent to PGE₂ in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE₂.¹

1 Bundy, G.L., Kimball, F.A., Robert, A., et al. Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins. Adv Prostaglandin Thromboxane Res 6 355-363 (1980).

Synonyms	9-deoxy-9-methylene PGE2
Formal Name	9-methylene-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number	61263-32-9
Molecular Formula	C₂₁H₃₄O₄
Formula Weight	350.5
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@@H](C/C=C\CCCC(O)=O)C(C1)=C

Background Reading

Bundy, G.L., Kimball, F.A., Robert, A., et al. Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins. Adv Prostaglandin Thromboxane Res 6 355-363 (1980).

Takasuka, M., Kishi, M., and Yamakawa, M. FTIR spectral study of intramolecular hydrogen bonding in thromboxane A₂ receptor agonist (U-46619), prostaglandin (PG)E₂, PGD₂, PGF_2α, prostacyclin receptor agonist (carbacyclin), and their related compounds in dilute CCl4 solution: Structure-activity relationships. J Med Chem 37 47-56 (1994).

Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship. Adv Prostaglandin Thromboxane Res 7 969-980 (1980).

Steffenrud, S. Metabolism of prostaglandin E analogs in the guinea pig liver mitrochondrial fraction. Biochem Med 32 161-180 (1984).

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9-deoxy-9-methylene Prostaglandin E2 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$54.00		$0.00
5 mg	$243.00		$0.00
10 mg	$432.00		$0.00
100 mg	$3,240.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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9-deoxy-9-methylene Prostaglandin E2