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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

11-deoxy-16,16-dimethyl Prostaglandin E2

Cayman Chemical Item Number 14570

11-deoxy-16,16-dimethyl PGE2 (CAS 53658-98-3)

11-deoxy-16,16-dimethyl Prostaglandin E2 (CAS 53658-98-3)

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Description

11-deoxy-16,16-dimethyl PGE2 is a stable synthetic analog of PGE2. It is an agonist for both EP2 and EP3 receptors.1 It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED50 values of 1 mg/kg and 0.021 mg/kg respectively.2 It is 900 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.3

1 Parrott, R.F., and Vellucci, S.V. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. Brain Res Bull 41 97-103 (1996).

2 Lippmann, W. Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-Hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids. Prostaglandins 7 231-246 (1974).

3 Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship. Adv Prostaglandin Thromboxane Res 7 969-980 (1980).

Synonyms
  • 11-deoxy-16,16-dimethyl PGE2
Formal Name 9-​oxo-​15R-​hydroxy-​16,​16-​dimethyl-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 53658-98-3
Molecular Formula C22H36O4
Formula Weight 364.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1[C@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​C(C)​(C)​CCCC)​CC1

Background Reading

Lippmann, W. Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-Hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids. Prostaglandins 7 231-246 (1974).

Parrott, R.F., and Vellucci, S.V. Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. Brain Res Bull 41 97-103 (1996).

Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship. Adv Prostaglandin Thromboxane Res 7 969-980 (1980).

11-deoxy-16,16-dimethyl Prostaglandin E2 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
50 mg $1,610.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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