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17-phenyl trinor Prostaglandin E₂

Cayman Chemical Item Number 14810

17-phenyl trinor PGE₂ (CAS 38315-43-4)

17-phenyl trinor Prostaglandin E2 (CAS 38315-43-4)

See more	Cannabinoids (296) Prostaglandins (513) Receptor Agonist (48) Neuroscience (654)

Description

17-phenyl trinor PGE₂ is a synthetic analog of PGE₂. It is an EP₁ and EP₃ receptor agonist.^1,2 17-phenyl trinor PGE₂ causes contraction of the guinea pig ileum at a concentration of 11 µM.¹ It is slightly less potent than PGE₂ in stimulating gerbil colon and rat uterus.² With an ED₅₀ value of 350 µg/kg, 17-phenyl trinor PGE₂ is 4.4 times more potent than PGE₂ as an antifertility agent in hamsters.²

1 Lawrence, R.A., Jones, R.L., and Wilson, N.H. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. Br J Pharmacol 105 271-278 (1992).

2 Miller, W.L., Weeks, J.R., Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9 9-18 (1975).

Synonyms	17-phenyl trinor PGE2
Formal Name	9-oxo-11α,15S-dihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid
CAS Number	38315-43-4
Molecular Formula	C₂₃H₃₀O₅
Formula Weight	386.5
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC(=O)CCC/C=C\CC1C(=O)CC(O)[C@@H]1\C=C\C(O)CCc1ccccc1

Background Reading

Miller, W.L., Weeks, J.R., Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9 9-18 (1975).

Chen, J., and Woodward, D.F. Prostanoid-induced relaxation of precontracted cat ciliary muscle is mediated by EP₂ and DP receptors. Invest Ophthamol Vis Sci 33 3195-3201 (1992).

Schaaf, T.K., Johnson, M.R., Constantine, J.W., et al. Structure-activity studies of configurationally rigid arylprostaglandins. J Med Chem 26 328-334 (1983).

Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. J Reprod Fertil 103 55-61 (1995).

Lawrence, R.A., Jones, R.L., and Wilson, N.H. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. Br J Pharmacol 105 271-278 (1992).

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17-phenyl trinor Prostaglandin E2 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
500 µg	$31.00		$0.00
1 mg	$59.00		$0.00
5 mg	$248.00		$0.00
10 mg	$434.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-10. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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17-phenyl trinor Prostaglandin E2