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Prostaglandin E₃ Exclusive

Cayman Chemical Item Number 14990

PGE₃ (CAS 802-31-3)

Prostaglandin E3 (CAS 802-31-3)

See more	Prostaglandins (513) Ophthalmology (61)

Description

Prostaglandin E₃ (PGE₃) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid.¹ In human ocular tissue, it comprises 2.4% of the COX products formed.¹ When applied to the eyes of a rabbit, a 1 µg dose of PGE₃ decreases intraocular pressure from 21 mmHg to about 17 mmHg.²

1 Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31 1159-1164 (1986).

2 Kulkarni, P.S., and Srinivasan, B.D. Prostaglandins E₃ and D₃ lower intraocular pressure. Invest Ophthamol Vis Sci 26 1178-1182 (1985).

Synonyms	PGE3
Formal Name	9-oxo-11α,15S-dihydroxy-prosta-5Z,13E,17Z-trien-1-oic acid
CAS Number	802-31-3
Molecular Formula	C₂₀H₃₀O₅
Formula Weight	350.5
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)C/C=C\CC)[C@H](O)C1

Background Reading

Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J Ocul Pharmacol 3 349-356 (1987).

Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31 1159-1164 (1986).

Kulkarni, P.S., and Srinivasan, B.D. Prostaglandins E₃ and D₃ lower intraocular pressure. Invest Ophthamol Vis Sci 26 1178-1182 (1985).

Prostaglandin E3 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
50 µg	$71.00		$0.00
100 µg	$135.00		$0.00
500 µg	$568.00		$0.00
1 mg	$994.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Prostaglandin E3 Exclusive