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Prostaglandin F1α

Cayman Chemical Item Number 15010

PGF1α (CAS 745-62-0)

Prostaglandin F1α (CAS 745-62-0)

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Description

Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M.1 PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α.2 It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.3

1 Moore, A., and Waring, C.P. Electrophysiological and endocrinological evidence that F-series prostaglandins function as priming pheromones in mature male Atlantic salmon (Salmo salar) PARR. J Exp Biol 199 2307-2316 (1996).

2 Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem Pharmacol 38 2375-2381 (1989).

3 Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship. Adv Prostaglandin Thromboxane Res 7 969-980 (1980).

Synonyms
  • PGF1α
Formal Name 9α,​11α,​15S-​trihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 745-62-0
Molecular Formula C20H36O5
Formula Weight 356.5
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(O)​C1CCCCCCC(=O)​O

Background Reading

Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem Pharmacol 38 2375-2381 (1989).

Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R. Prostaglandins and human respiratory tract smooth muscle: Structure activity relationship. Adv Prostaglandin Thromboxane Res 7 969-980 (1980).

Moore, A., and Waring, C.P. Electrophysiological and endocrinological evidence that F-series prostaglandins function as priming pheromones in mature male Atlantic salmon (Salmo salar) PARR. J Exp Biol 199 2307-2316 (1996).

Prostaglandin F1α is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $34.00 $0.00
5 mg $153.00 $0.00
10 mg $272.00 $0.00
50 mg $1,190.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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