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6-keto Prostaglandin F_1α

Cayman Chemical Item Number 15210

6-keto PGF_1α (CAS 58962-34-8)

6-keto Prostaglandin F1α (CAS 58962-34-8)

See more	Eicosanoids (216) Prostaglandins (513) Atherosclerosis (323) Cardiology (79) Vascular Disease (103)

Description

6-keto prostaglandin F_1α (6-keto PGF_1α) is the inactive, non-enzymatic hydrolysis product of PGI₂.^1,2 6-keto PGF_1α serves as a useful marker of PGI₂ biosynthesis in vivo.³ When [³H]-PGI₂ is injected into healthy human males, 6.6% of the radioactivity is recovered from urine as [³H]-6-keto PGF_1α.³

1 Pace-Asciak, C.R. Isolation, structure, and biosynthesis of 6-ketoprostaglandin F_1α in the rat stomach. J Am Chem Soc 98 2348-2349 (1976).

2 Johnson, R.A., Morton, D.R., Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins 12 915-928 (1976).

3 Brash, A.R., Jackson, E.K., Saggese, C.A., et al. Metabolic disposition of prostacyclin in humans. J Pharmacol Exp Ther 226 78-87 (1983).

Synonyms	6-keto PGF1α
Formal Name	6-oxo-9α,11α,15S-trihydroxy-prost-13E-en-1-oic acid
CAS Number	58962-34-8
Molecular Formula	C₂₀H₃₄O₆
Formula Weight	370.5
Formulation	A crystalline solid
Purity	>99%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@@H]1[C@H](CC(CCCCC(O)=O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1

Background Reading

Brash, A.R., Jackson, E.K., Saggese, C.A., et al. Metabolic disposition of prostacyclin in humans. J Pharmacol Exp Ther 226 78-87 (1983).

Johnson, R.A., Morton, D.R., Kinner, J.H., et al. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins 12 915-928 (1976).

Pace-Asciak, C.R. Isolation, structure, and biosynthesis of 6-ketoprostaglandin F_1α in the rat stomach. J Am Chem Soc 98 2348-2349 (1976).

6-keto Prostaglandin F1α is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$80.00		$0.00
5 mg	$360.00		$0.00
10 mg	$640.00		$0.00
50 mg	$2,800.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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6-keto Prostaglandin F1α