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11-deoxy Prostaglandin F_1α

Cayman Chemical Item Number 15512

11-deoxy PGF_1α (CAS 37785-98-1)

11-deoxy Prostaglandin F1α (CAS 37785-98-1)

See more	Prostaglandins (513)

Description

11-deoxy PGF_1α is a synthetic analog of PGF_1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%.¹ 11-deoxy PGF_1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF_1α.² It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF_2α in guinea pigs.³

1 Lippmann, W. Inhibition of gastric acid secretion in the rat by synthetic prostaglandins. J Pharm Pharmacol 21 335-336 (1969).

2 Broughton, B.J., Caton, M.P.L., Christmas, A.J., et al. Uterine stimulant action of some ω-chain modified (±)-11-deoxyprostaglandins. Prostaglandins 22 53-64 (1981).

3 Hall, D.W.R., and Jaitly, K.D. Structure-activity relationships in a series of 11-deoxy prostaglandins. Prostaglandins 11 573-587 (1976).

Synonyms	11-deoxy PGF1α
Formal Name	9α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number	37785-98-1
Molecular Formula	C₂₀H₃₆O₄
Formula Weight	340.5
Formulation	A crystalline solid
Purity	>99%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)CC1

Background Reading

Lippmann, W. Inhibition of gastric acid secretion in the rat by synthetic prostaglandins. J Pharm Pharmacol 21 335-336 (1969).

Broughton, B.J., Caton, M.P.L., Christmas, A.J., et al. Uterine stimulant action of some ω-chain modified (±)-11-deoxyprostaglandins. Prostaglandins 22 53-64 (1981).

Nakano, J. Relationship between the chemical structure of prostaglandins and their vasoactivities in dogs. Br J Pharmacol 44 63-70 (1972).

Hall, D.W.R., and Jaitly, K.D. Structure-activity relationships in a series of 11-deoxy prostaglandins. Prostaglandins 11 573-587 (1976).

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11-deoxy Prostaglandin F1α is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$38.00		$0.00
5 mg	$171.00		$0.00
10 mg	$304.00		$0.00
50 mg	$1,330.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Prostaglandin F_1α

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11-deoxy Prostaglandin F1α