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Prostaglandin F_2α

Cayman Chemical Item Number 16010

PGF_2α; Dinoprost (CAS 551-11-1)

Prostaglandin F2α (CAS 551-11-1)

See more	Prostaglandins (513)

Description

Prostaglandin F_2α (PGF_2α) is a widely distributed PG occurring in many species.^1,2,3 It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.² PGF_2α exerts its receptor mediated physiological activity at 50-100 nM.² Maximal ovine myometrial contraction can be achieved at 125 nM PGF_2α in vitro.⁴

1 Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology. Am J Obstet Gynecol 107 1111-1130 (1970).

2 Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu Rev Biochem 47 997-1029 (1978).

3 Watanabe, K., Iguchi, Y., Iguchi, S., et al. Stereospecific conversion of prostaglandin D₂ to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H₂ to prostaglandin F_2α by bovine lung prostaglandin F synthase. Proc Natl Acad Sci USA 83 1583-1587 (1986).

4 Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. J Reprod Fertil 103 55-61 (1995).

Synonyms	PGF2α Dinoprost
Formal Name	9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number	551-11-1
Molecular Formula	C₂₀H₃₄O₅
Formula Weight	354.5
Formulation	A crystalline solid
Purity	>99%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)/C=C/[C@H]1C(O)CC(O)C1C/C=C\CCCC(=O)O

Background Reading

Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu Rev Biochem 47 997-1029 (1978).

Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology. Am J Obstet Gynecol 107 1111-1130 (1970).

Watanabe, K., Iguchi, Y., Iguchi, S., et al. Stereospecific conversion of prostaglandin D₂ to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H₂ to prostaglandin F_2α by bovine lung prostaglandin F synthase. Proc Natl Acad Sci USA 83 1583-1587 (1986).

Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes. J Reprod Fertil 103 55-61 (1995).

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Prostaglandin F2α is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$27.00		$0.00
5 mg	$122.00		$0.00
10 mg	$216.00		$0.00
50 mg	$945.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Prostaglandin F2α