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COX-2 (human) Polyclonal Antibody

Cayman Chemical Item Number 160107

PGHS-2; Prostaglandin H Synthase 2; Cyclooxygenase 2

COX-2 (human) Polyclonal Antibody

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Description

Antigen: human COX-2 amino acids 567-599 (SVPDPELIKTVTINASSSRSGLDDINPTVLLKE) · Host: rabbit · Application(s): WB · COX-2 has been cloned from a variety of species including human, rat, and sheep and has a molecular weight of 72 kDa.1,2,3,4, COX-2 from these species are approximately 90% identical at the amino acid level, whereas the homology between COX-1 and COX-2 is only about 60%. Expression of COX-2 is regulated by growth factors, tumor promoters, bacterial endotoxin and cytokines, including IL-1β.5,6 COX-2 is present in human breast tumors but is not expressed in normal breast tissue.7

1 Hla, T., and Neilson, K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 89 7384-7388 (1992).

2 Kujubu, D.A., Fletcher, B.S., Varnum, B.C., et al. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266 12866-12872 (1991).

3 Yamagata, K., Andreasson, K.I., Kaufmann, W.E., et al. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids. Neuron 11 371-386 (1993).

4 Zhang, V., O'Sullivan, M., Hussain, H., et al. Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2. Biochem Biophys Res Commun 227 499-506 (1996).

5 Camacho, M., Godessart, N., Anton, R., et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J Biol Chem 270 17279-17286 (1995).

6 Croxtall, J.D., Newman, S.P., Choudhury, Q., et al. The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1β in A549 cells. Biochem Biophys Res Commun 220 491-495 (1996).

7 Parrett, M.L., Harris, R.E., Joarder, F.S., et al. Cyclooxygenase-2 gene expression in human breast cancer. Int J Oncol 10 503-507 (1997).

Synonyms
  • PGHS-2
  • Prostaglandin H Synthase 2
  • Cyclooxygenase 2
Formulation Affinity-purified IgG
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human COX-2 +
Mouse COX-2
Ovine COX-2 +
COX-1 (all species) -
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Background Reading

Hla, T., and Neilson, K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 89 7384-7388 (1992).

Kujubu, D.A., Fletcher, B.S., Varnum, B.C., et al. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266 12866-12872 (1991).

Camacho, M., Godessart, N., Anton, R., et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J Biol Chem 270 17279-17286 (1995).

Croxtall, J.D., Newman, S.P., Choudhury, Q., et al. The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1β in A549 cells. Biochem Biophys Res Commun 220 491-495 (1996).

Yamagata, K., Andreasson, K.I., Kaufmann, W.E., et al. Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids. Neuron 11 371-386 (1993).

Zhang, V., O'Sullivan, M., Hussain, H., et al. Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2. Biochem Biophys Res Commun 227 499-506 (1996).

Parrett, M.L., Harris, R.E., Joarder, F.S., et al. Cyclooxygenase-2 gene expression in human breast cancer. Int J Oncol 10 503-507 (1997).

Appleby, S.B., Ristimäki, A., Neilson, K., et al. Structure of the human cyclo-oxygenase-2 gene. Biochem J 302 723-727 (1994).

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Size Price Quantity Subtotal
1 ea $177.00 $0.00
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Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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