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Prostaglandin F_2α methyl ester

Cayman Chemical Item Number 16011

PGF_2α methyl ester (CAS 33854-16-9)

Prostaglandin F2α methyl ester (CAS 33854-16-9)

See more	Prostaglandins (517)

Description

Prostaglandin F_2α methyl ester (PGF_2α methyl ester) is an analog of PGF_2α in which the C-1 carboxyl group has been esterified as the methyl ester. PGF_2α methyl ester was one of the first PG esters shown to have ocular hypotensive activity.¹ This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF_2α. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 µg dose of PGF_2α-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.¹

1 Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

Synonyms	PGF2α methyl ester
Formal Name	9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, methyl ester
CAS Number	33854-16-9
Molecular Formula	C₂₁H₃₆O₅
Formula Weight	368.5
Formulation	A solution in methyl acetate
Purity	>98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)/C=C/[C@H]1C(O)CC(O)C1C/C=C\CCCC(=O)OC

Background Reading

Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

Prostaglandin F2α methyl ester is available in the following screening libraries:

Size	Price	Quantity	Subtotal
500 µg	$22.00		$0.00
1 mg	$42.00		$0.00
5 mg	$176.00		$0.00
10 mg	$308.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Prostaglandin F2α methyl ester