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Prostaglandin F2α Alcohol

Cayman Chemical Item Number 16012

ZK 62717; PGF2α-OH; AGN190190 (CAS 13261-27-3)

Prostaglandin F2α Alcohol (CAS 13261-27-3)

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Description

Prostaglandin F2α alcohol (PGF2α-OH) is an analog of PGF2α in which the C-1 carboxyl group has been reduced to a primary alcohol. Biological studies on rat uterus show it to be a weak agonist.1 The compound is reported to retain ocular hypotensive properties,2 but the nature of the receptors which mediate these effects is disputed.3

1 Brambaifa, N. Luteolytic potency of PGD and PGF2α derivatives. Eur J Obstet Gynecol Reprod Biol 27 319-325 (1988).

2 Woodward, D.F., and Chan, M.F. Preparation of PGF-1 alcohols as ocular hypotensives. 38204 1-12 (1993).

3 Woodward, D.F., Krauss, A.H., Chen, J., et al. Replacement of the carboxylic acid group of prostaglandin F2α with a hydroxyl or methoxy substituent provides biologically unique compounds. Br J Pharmacol 130 1933-1943 (2000).

Synonyms
  • ZK 62717
  • PGF2α-OH
  • AGN190190
Formal Name 1,​9α,​11α,​15S-​tetrahydroxyprosta-​5Z,​13E-​diene
CAS Number 13261-27-3
Molecular Formula C20H36O4
Formula Weight 340.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(O)​C1C/C=C\CCCCO

Background Reading

Woodward, D.F., and Chan, M.F. Preparation of PGF-1 alcohols as ocular hypotensives. 38204 1-12 (1993).

Brambaifa, N. Luteolytic potency of PGD and PGF2α derivatives. Eur J Obstet Gynecol Reprod Biol 27 319-325 (1988).

Woodward, D.F., Krauss, A.H., Chen, J., et al. Replacement of the carboxylic acid group of prostaglandin F2α with a hydroxyl or methoxy substituent provides biologically unique compounds. Br J Pharmacol 130 1933-1943 (2000).

Prostaglandin F2α Alcohol is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
50 mg $1,610.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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