See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin F2α Ethanolamide

Cayman Chemical Item Number 16013

PGF2α-EA; Dinoprost Ethanolamide (CAS 353787-70-9)

Prostaglandin F2α Ethanolamide (CAS 353787-70-9)

See more

Description

Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues.1 AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs.2,3 PGF2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2α-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.4

1 Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2 Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

3 Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

4 Woodward, D.F., Tang-Liu, D.D., Madhu, C., et al. Prostaglandin F2α (PGF2α) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide. 27 (2000).

Synonyms
  • PGF2α-EA
  • Dinoprost Ethanolamide
Formal Name N-​(2-​hydroxyethyl)-​9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​amide
CAS Number 353787-70-9
Molecular Formula C22H39NO5
Formula Weight 397.5
Formulation A solution in ethanol
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(O)​C1C/C=C\CCCC(=O)​NCCO

Background Reading

Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

Woodward, D.F., Tang-Liu, D.D., Madhu, C., et al. Prostaglandin F2α (PGF2α) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide. 27 (2000).

Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

Show all 4 Hide all but first 3

Prostaglandin F2α Ethanolamide is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $52.00 $0.00
5 mg $234.00 $0.00
10 mg $416.00 $0.00
50 mg $1,820.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

8-iso Prostaglandin F2α Ethanolamide
Leukotriene B4 Ethanolamide
Prostaglandin D2 Ethanolamide
Prostaglandin E1 Ethanolamide
Prostaglandin E2 Ethanolamide Exclusive
Prostaglandin F2α Ethanolamide-d4
Prostaglandin F2α Ethanolamide Lipid Maps MS Standard
Prostaglandin F2α serinol amide
Tiaprost New
Show all 9 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?