See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

Prostaglandin E Synthase-1 (microsomal) Polyclonal Antibody

Cayman Chemical Item Number 160140

mPGES-1; mPGE Synthase-1; Prostaglandin H/E Isomerase; PIG12; Membrane-Associated PGES-1; MGST1-L1

Prostaglandin E Synthase-1 (microsomal) Polyclonal Antibody

See more

Description

Antigen: human mPGE synthase amino acids 59-75 (CRSDPDVERSLRAHRND) · Host: rabbit · Application(s): WB and IHC; other applications not tested · Prostaglandin E Synthase-1 (PGES-1) catalyzes the isomerization of PGH2 to PGE2. PGE2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 PGES-1 is a 16 kDa membrane-associated protein with glutathione-dependent activity.5 The mRNA is for PGES-1 is expressed in a variety of tissues including prostate, testes, and small intestine, as well as in A549 and HeLa cells.5 PGES-1 protein expression is increased in A549 cells following treatment with IL-1β5

1 Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3 353-357 (1973).

2 Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am J Obstet Gynecol 171 1092-1096 (1994).

3 Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70 359-370 (1976).

4 Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34 5604-5609 (1995).

5 Jakobsson, P., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96 7220-7225 (1999).

Synonyms
  • mPGES-1
  • mPGE Synthase-1
  • Prostaglandin H/E Isomerase
  • PIG12
  • Membrane-Associated PGES-1
  • MGST1-L1
Formulation Peptide affinity-purified IgG
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human mPGES +
Mouse mPGES +
Ovine mPGES +
Rat mPGES +
cPGES -
Show all 5 Hide all but first 3

Background Reading

Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34 5604-5609 (1995).

Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocin. Am J Obstet Gynecol 171 1092-1096 (1994).

Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3 353-357 (1973).

Guan, Y., Zhang, Y., Schneider, A., et al. Urogenital distribution of a mouse membrane-associated prostaglandin E2 synthase. Am J Physiol Renal Physiol 281 F1173-F1177 (2001).

Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70 359-370 (1976).

Jakobsson, P., Thorén, S., Morgenstern, R., et al. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96 7220-7225 (1999).

Mancini, J.A., Blood, K., Guay, J., et al. Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. J Biol Chem 276 4469-4475 (2001).

Yamagata, K., Matsumura, K., Inoue, W., et al. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 21(8) 2669-2677 (2001).

Show all 8 Hide all but first 3
Size Price Quantity Subtotal
Trial

Sufficient for 3 western blots

 $102.00 $0.00
500 µl $206.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

CAY10526 Exclusive
COX-2 (human) Polyclonal Antibody
COX-2 Monoclonal Antibody (Clone CX229)
Prostaglandin E2
Prostaglandin E2 EIA Kit - Monoclonal
Prostaglandin E2 Express EIA Kit
Prostaglandin E Synthase-1 (microsomal) Blocking Peptide
Prostaglandin E Synthase-1 (microsomal) (human recombinant)
Prostaglandin E Synthase-1 (microsomal) Monoclonal Antibody (Clone 6C6)
Prostaglandin E Synthase-1 (microsomal) Western Ready Control
Prostaglandin E Synthase-2 (microsomal) Polyclonal Antibody
Prostaglandin E Synthase (cytosolic) Blocking Peptide
Prostaglandin E Synthase (cytosolic) Polyclonal Antibody
Prostaglandin E Synthase (cytosolic) Western Ready Control
Prostaglandin H2
Show all 15 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?