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12-Lipoxygenase (murine leukocyte) Polyclonal Antiserum

Cayman Chemical Item Number 160304

12-LO; 12-LOX

See more	Western Blot (567) Antibodies (677) Eicosanoids (216) Atherosclerosis (325)

Description

Antigen: recombinant mouse leukocyte 12-LO · Host: rabbit · Application(s): WB; other applications not tested · Leukocyte-type 12-lipoxygenase from murine macrophages is a 75 kDa protein.¹ Murine leukocyte 12-lipoxygenase is approximately 70% homologous to porcine 12-lipoxygenase and also shows 78% and 77% identity to human and rabbit 15-lipoxygenase, respectively.^1,2 This antibody can be used to detect the leukocyte-type 12-lipoxygenase in immunoblotting experiments.

1 Chen, X., Kurre, U., Jenkins, N.A., et al. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem 269 13979-13987 (1994).

2 Yoshimoto, T., Suzuki, H., Yamamoto, S., et al. Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes. Proc Natl Acad Sci USA 87 2142-2146 (1990).

Synonyms

12-LO
12-LOX

Formulation

100 µl lyophilized antiserum

Stability

2 years

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human leukocyte 12-LO	+
Mouse leukocyte 12-LO	+
Porcine leukocyte 12-LO	+
Rabbit reticulocyte 15-LO	+

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Background Reading

Yoshimoto, T., Suzuki, H., Yamamoto, S., et al. Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes. Proc Natl Acad Sci USA 87 2142-2146 (1990).

Freire-Moar, J., Alavi-Nassab, A., Ng, M., et al. Cloning and characterization of a murine macrophage lipoxygenase. Biochim Biophys Acta 1254 112-116 (1995).

Chen, X., Kurre, U., Jenkins, N.A., et al. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. J Biol Chem 269 13979-13987 (1994).

Size	Price	Quantity	Subtotal
1 ea	$187.00		$0.00
Bulk	Contact
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Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

15-Lipoxygenase-1 (rabbit) Polyclonal Antiserum

5-Lipoxygenase Polyclonal Antibody

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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