Antigen: human recombinant sPLA₂ Type IIA · Clone designation: SCACC353 · Host: mouse · Isotype: IgG₁ · Application(s): WB and IP; other applications not tested · Phospholipase A₂ (PLA₂) catalyzes the hydrolysis of phospholipids at the sn-2 position yielding a free fatty acid and a lysophospholipid.¹ The release of arachidonic acid from membrane phospholipids by PLA₂ is believed to be a key step in the control of eicosanoid production within the cell.² Human synovial sPLA₂ is a secreted, 14 kDa protein which is dependent on Ca2+ for optimal activity. Human synovial sPLA₂ is 79% homologous to rat platelet and mouse type II sPLA₂s.

1 Dennis, E.A. Phospholipases. Enzymes XVI 307-353 (1983).

2 Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A₂. J Biol Chem 269 13057-13060 (1994).

Dennis, E.A. Phospholipases. Enzymes XVI 307-353 (1983).

Hulthe, J., Wiklund, O., Hurt-Camejo, E., et al. Antibodies to oxidized LDL in relation to carotid atherosclerosis, cell adhesion molecules, and phospholipase A₂. Arterioscler Thromb Vasc Biol 21 269-274 (2001).

Peilot, H., Rosengren, B., Bondjers, G., et al. Interferon-γ induces secretory group IIA phospholipase A₂ in human arterial smooth muscle cells. Involvement of cell differentiation, stat-3 activation, and modulation by other cytokines . J Biol Chem 275 (30) 22895-22904 (2000).

Dennis, E.A. Diversity of group types, regulation, and function of phospholipase A₂. J Biol Chem 269 13057-13060 (1994).

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