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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

15-hydroxy Prostaglandin Dehydrogenase Polyclonal Antibody

Cayman Chemical Item Number 160615

15-hydroxy PGDH

15-hydroxy Prostaglandin Dehydrogenase Polyclonal Antibody

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Description

Antigen: human NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) amino acids 92-105 (AGVNNEKNWEKTLQ) · Host: rabbit · Application(s): WB; other applications not tested · NAD+-dependent 15-hydroxy PGDH catalyzes the oxidation of prostaglandins to 15-keto metabolites, which have greatly reduced biological activity.1 Human NAD+-dependent 15-hydroxy PGDH is a 266 amino acid protein with a molecular weight of 29 kDa and is expressed in multiple tissues including lung, placenta, and kidney.2 The enzyme belongs to a large family of short-chain alcohol dehydrogenases, which exhibit amino acid identity ranging from 15-30%.3,4 An NADP+-dependent 15-hydroxy PGDH, which is also part of this enzyme family, exhibits only 20% amino acid identity to the NAD+-dependent enzyme.5 The peptide used as the antigen for preparation of the 15-hydroxy PGDH antibody is highly conserved across several species (see above), but has only minor homology to other proteins within the short-chain alcohol dehydrogenase family of enzymes (only the alanine and glycine at the N-terminus of the sequence appear to be conserved).3

1 Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review. Prostaglandins 12 647-679 (1976).

2 Ensor, C.M., Yang, J., Okita, R.T., et al. Cloning and sequence analysis of the cDNA for human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. J Biol Chem 265 14888-14891 (1990).

3 Jörnvall, H., Persson, B., Krook, M., et al. Short-chain dehydrogenases/reductases (SDR). Biochemistry 34 6003-6013 (1995).

4 Krook, M., Marekov, L., and Jörnvall, H. Purification and structural characterization of placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family. Biochemistry 29 738-743 (1990).

5 Wermuth, B. NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases. Prostaglandins 44 5-9 (1992).

Synonyms
  • 15-hydroxy PGDH
Formulation Peptide affinity-purified IgG
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human 15-hydroxy PGDH +
Bovine 15-hydroxy PGDH +
Guinea pig 15-hydroxy PGDH +
Baboon 15-hydroxy PGDH +
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Background Reading

Hansen, H.S. 15-Hydroxyprostaglandin dehydrogenase. A review. Prostaglandins 12 647-679 (1976).

Ensor, C.M., Yang, J., Okita, R.T., et al. Cloning and sequence analysis of the cDNA for human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. J Biol Chem 265 14888-14891 (1990).

Jörnvall, H., Persson, B., Krook, M., et al. Short-chain dehydrogenases/reductases (SDR). Biochemistry 34 6003-6013 (1995).

Wermuth, B. NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases. Prostaglandins 44 5-9 (1992).

Krook, M., Marekov, L., and Jörnvall, H. Purification and structural characterization of placental NAD+-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family. Biochemistry 29 738-743 (1990).

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Size Price Quantity Subtotal
500 µl $161.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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