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Antigen:
bovine lung PGIS
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Clone designation:
isn-1
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Host:
mouse
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Isotype:
IgG1
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Application(s):
IP and IHC; WB not recommended
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PGI synthase (PGIS) catalyzes the conversion of PGH2 to PGI2 (prostacyclin). Human lung PGIS is a 56 kDa protein. The cloned bovine and human enzymes contain 500 amino acids and have a calculated molecular mass of 56,629 and 57,103, respectively.1,2,3 There is 88% homology between human and bovine PGIS.
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1
Miyata, A., Hara, S., Yokoyama, C., et al. Molecular cloning and expression of human prostacyclin synthase. Biochem Biophys Res Commun 200 1728-1734 (1994).
2
Pereira, B., Wu, K.K., Wang, L. Molecular cloning and characterization of bovine prostacyclin synthase. Biochem Biophys Res Commun 203 59-66 (1994).
3
Hara, S., Miyata, A., Yokoyama, C., et al. Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells. J Biol Chem 269 19897-19903 (1994).
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