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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

ARC Polyclonal Antibody

Cayman Chemical Item Number 160737

Apoptosis Repressor with CARD

ARC Polyclonal Antibody

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Description

Antigen: human ARC amino acids 191-208 (PDPEPEPDFEERDESEDS) · Host: rabbit · Application(s): WB and IP · Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators included RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD.1 ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The mRNA for ARC is expressed primarily in skeletal muscle and cardiac tissues.1

1 Koseki, T., Inohara, N., Chen, S., et al. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci USA 95 5156-5160 (1998).

Synonyms
  • Apoptosis Repressor with CARD
Formulation 100 µg affinity-purified IgG in 200 µl PBS containing 0.02% sodium azide
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere

Background Reading

Koseki, T., Inohara, N., Chen, S., et al. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci USA 95 5156-5160 (1998).
Size Price Quantity Subtotal
1 ea $161.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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