Antigen: human TRAIL amino acids 261-277 (CTNEHLIDMDHEASFFGA) · Host: rabbit · Application(s): WB · Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR-1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (TNF-related apoptosis-inducing ligand) and Apo-2L (Apo-2 ligand).^1,2 TRAIL is a type II membrane protein and is expressed in a variety of human tissues.¹ Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL.^3,4,5,6 Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.

1 Pitti, R.M., Marsters, S.A., Ruppert, S., et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271 12687-12690 (1996).

2 Wiley, S.R., Schooley, K., Smolak, P.J., et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3 673-682 (1995).

3 Pan, G., O'Rourke, K., Chinnaiyan, A.M., et al. The receptor for the cytotoxic ligand TRAIL. Science 276 111-113 (1997).

4 Schneider, P., Thome, M., Burns, K., et al. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB. Immunity 7 831-836 (1997).

5 Pan, G., Ni, J., Wei, Y., et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 815-817 (1997).

6 Sheridan, J.P., Marsters, S.A., Pitti, R.M., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 818-821 (1997).

Pan, G., Ni, J., Wei, Y., et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 815-817 (1997).

Pitti, R.M., Marsters, S.A., Ruppert, S., et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem 271 12687-12690 (1996).

Sheridan, J.P., Marsters, S.A., Pitti, R.M., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 818-821 (1997).

Pan, G., O'Rourke, K., Chinnaiyan, A.M., et al. The receptor for the cytotoxic ligand TRAIL. Science 276 111-113 (1997).

Schneider, P., Thome, M., Burns, K., et al. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB. Immunity 7 831-836 (1997).

Wiley, S.R., Schooley, K., Smolak, P.J., et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3 673-682 (1995).

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