See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

DcR2 Polyclonal Antibody

Cayman Chemical Item Number 160755

TRUNDD; TRAIL-R4

See more

Description

Antigen: human DcR2 precursor amino acids 249-263 (GGPERVHRVLFRRRS) · Host: rabbit · Application(s): WB · Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor.1,2,3 Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD.4,5,6 DcR2 has an extracellular TRAIL-binding domain but lacks an intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuates TRAIL-induced apoptosis.

1 Pan, G., O'Rourke, K., Chinnaiyan, A.M., et al. The receptor for the cytotoxic ligand TRAIL. Science 276 111-113 (1997).

2 Pan, G., Ni, J., Wei, Y., et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 815-817 (1997).

3 Sheridan, J.P., Marsters, S.A., Pitti, R.M., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 818-821 (1997).

4 Marsters, S.A., Sheridan, J.P., Pitti, R.M., et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 7 1003-1006 (1997).

5 Degli-Esposti, M.A., Dougall, W.C., Smolak, P.J., et al. The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7 813-820 (1997).

6 Pan, G., Ni, J., Yu, G., et al. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett 424 41-45 (1998).

Synonyms
  • TRUNDD
  • TRAIL-R4
Formulation 100 µg affinity-purified IgG in 200 µl PBS containing 0.02% sodium azide
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human DcR2 +

Background Reading

Pan, G., Ni, J., Wei, Y., et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 815-817 (1997).

Sheridan, J.P., Marsters, S.A., Pitti, R.M., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 818-821 (1997).

Degli-Esposti, M.A., Dougall, W.C., Smolak, P.J., et al. The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7 813-820 (1997).

Marsters, S.A., Sheridan, J.P., Pitti, R.M., et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 7 1003-1006 (1997).

Pan, G., Ni, J., Yu, G., et al. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett 424 41-45 (1998).

Pan, G., O'Rourke, K., Chinnaiyan, A.M., et al. The receptor for the cytotoxic ligand TRAIL. Science 276 111-113 (1997).

Show all 6 Hide all but first 3
Size Price Quantity Subtotal
1 ea $213.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

TRAIL Polyclonal Antibody

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?