Cayman Chemical | Nod2 Polyclonal Antibody

160777 Nod2 Polyclonal Antibody

Click image to enlarge

• See below for pricing and ordering

• See analysis tools

• See more Immunoprecipitation; Western Blot; Immunology

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Antigen: recombinant human Nod2 residues 28-301 · Host: rabbit · Application(s): WB and IP; may not detect basal levels of Nod2 in monocytes · Nod2 is a member of a protein family of apoptosis regulators which includes Apaf-1 and Nod1/CARD4.¹ Nod2 contains two N-terminal caspase recruitment domains (CARDs), a nucleotide binding domain (NBD) and C-terminal leucine rich repeats (LRRs). Nod1/CARD4 is broadly expressed in tissues; however, Nod2 expression is limited to monocytes.^1,2 Both Nod1 and Nod2 activate NF-kB and act as intracellular receptors for bacterial lipopolysaccharides (LPS).^2,3,4,5 The LRRs of both Nod1 and Nod2 are essential for LPS-induced activation of NF-kB.⁴ A frameshift mutation in the NOD2 gene confers susceptibility to Crohn’s disease, possibly by causing truncation of the 10^th LRR resulting in a protein that is unresponsive to LPS.^6,7

1 Ogura, Y., Inohara, N., Benito, A., et al. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J Biol Chem 276 4812-4818 (2001).

2 Bertin, J., Nir, W., Fischer, C.M., et al. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB. J Biol Chem 274 12955-12958 (1999).

3 Inohara, N., Koseki, T., Lin, J., et al. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 275 27823-27831 (2000).

4 Inohara, N., Ogura, Y., Chen, F.F., et al. Human NOD1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276 2551-2554 (2001).

5 Inohara, N., Koseki, T., del Peso, L., et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. J Biol Chem 274 14560-14567 (1999).

6 Ogura, Y., Bonen, D.K., Inohara, N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411 603-606 (2001).

7 Hugot, J., Chamaillard, M., Zouali, H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411 599-603 (2001).

	Download Product Insert 187 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 160777 Nod2 Polyclonal Antibody

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-18.
Prices are subject to change without notice.