Antigen: human VE-cadherin amino acids 259-434 · Host: rabbit · Application(s): WB, IP, and ICC · VE-cadherin (vascular endothelium cadherin), also known as Cadherin-5, is an endothelial cell-specific adhesion molecule localized at intracellular junctions.^1,2,3 The protein belongs to the cadherin superfamily of adhesion molecules.⁴ VE-cadherin plays a pivotal role in vascular structure assembly. Endothelial cells fail to organize in a vessel-like pattern if the VE-cadherin gene is disrupted.⁵ In this aspect, VE-cadherin is a critical component of a protein complex which controls endothelial cell tube formation.⁶ VE-cadherin is also critical for maintenance of the endothelium. Following disruption of endothelial cell monolayers with an anti-VE-cadherin antibody, endothelial cells rapidly resynthesize VE-cadherin in order to restore their intracellular junctions.⁷ Human VE-cadherin has a molecular mass of approximately 87,500 based on the deduced amino acid sequence and is 83% and 79% homologous to porcine and mouse VE-cadherin at the amino acid level.

1 Suzuki, S., Sano, K., and Tanihara, H. Diversity of the cadherin family: Evidence for eight new cadherins in nervous tissue. Cell Regul 2 261-270 (1991).

2 missing reference text

3 Breviario, F., Caveda, L., Corada, M., et al. Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arterioscler Thromb Vasc Biol 15 1229-1239 (1995).

4 Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251 1451-1455 (1991).

5 Vittet, D., Buchou, T., Schweitzer, A., et al. Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc Natl Acad Sci USA 94 6273-6278 (1997).

6 Matsumura, T., Wolff, K., and Petzelbauer, P. Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J Immunol 158 3408-3416 (1997).

7 Gulino, D., Delachanal, E., Concord, E., et al. Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin. J Biol Chem 273 29786-29793 (1998).

Gulino, D., Delachanal, E., Concord, E., et al. Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin. J Biol Chem 273 29786-29793 (1998).

Matsumura, T., Wolff, K., and Petzelbauer, P. Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J Immunol 158 3408-3416 (1997).

Breviario, F., Caveda, L., Corada, M., et al. Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arterioscler Thromb Vasc Biol 15 1229-1239 (1995).

Vittet, D., Buchou, T., Schweitzer, A., et al. Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc Natl Acad Sci USA 94 6273-6278 (1997).

Lampugnani, M.G., Resnati, M., Raiteri, M., et al. A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol 118 1511-1522 (1992).

Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251 1451-1455 (1991).

Suzuki, S., Sano, K., and Tanihara, H. Diversity of the cadherin family: Evidence for eight new cadherins in nervous tissue. Cell Regul 2 261-270 (1991).

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