Cayman Chemical | Guanylate Cyclase α subunit (soluble) Polyclonal Antibody

160895 Guanylate Cyclase α subunit (soluble) Polyclonal Antibody

sGC α subunit

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Antigen: human guanylate cyclase α subunit amino acids 418-436 (EQARAQDGLKKRLGKLKAT) · Host: rabbit · Application(s): WB · Soluble guanylate cyclase is a heterodimeric enzyme, composed of α and β subunits, that synthesizes cGMP from GTP. The enzyme is activated by the binding of nitric oxide or carbon monoxide to the heme group of the enzyme.¹ Chronic hypoxia upregulates soluble guanylate expression in rat lung.² The α1 subunit contains 690-717 amino acids and has a molecular mass of 77-82 kDa.^3,4,5 The cloned β1 subunit of guanylate cyclase from human, bovine, and rat sources contains 619 amino acids and has a molecular mass of approximately 70,000.^3,6,7

1 Stone, J.R., Marletta, M.A. Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 33 5636-5640 (1994).

2 Li, D., Zhou, N., Johns, R.A. Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia. Am J Physiol 277 841-847 (1999).

3 Giuili, G., Scholl, U., Bulle, F., et al. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. FEBS Lett 304 83-88 (1992).

4 Nakane, M., Arai, K., Saheki, S., et al. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung. J Biol Chem 265 16841-16845 (1990).

5 Lee, M., Bell, R.M. Supplementation of the phosphatidyl-L-serine requirement of protein kinase C with nonactivating phospholipids. Biochemistry 31 5176-5182 (1992).

6 Koesling, D., Herz, J., Gausepohl, H., et al. The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase. FEBS Lett 239 29-34 (1988).

7 Nakane, M., Saheki, S., Kuno, T., et al. Molecular cloning of a cDNA coding for 70 kilodalton subunit of soluble guanylate cyclase from rat lung. Biochem Biophys Res Commun 157 1139-1147 (1988).

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Purchase 160895 Guanylate Cyclase α subunit (soluble) Polyclonal Antibody

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Pricing updated 2010-03-19.
Prices are subject to change without notice.