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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

2,3-dinor-8-iso Prostaglandin F2α

Cayman Chemical Item Number 16290

2,3-dinor-iPF2α-III; 2,3-dinor-8-iso PGF2α (CAS 221664-05-7)

2,3-dinor-8-iso Prostaglandin F2α (CAS 221664-05-7)

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Description

8-iso Prostaglandin F2α (8-iso PGF2α; 8-isoprostane) is a prostaglandin-like product of non-specific lipid peroxidation.1 2,3-dinor-8-iso PGF2α is a metabolite of 8-iso PGF2α in humans and rats.2 In these species, exogenously infused 8-iso PGF2α is converted to 2,3-dinor-8-iso PGF1α and (2,3-dinor-8-iso PGF2α.2,3 Rat hepatocytes further metabolize 8-iso PGF2α to another β-oxidation product, 2,3,4,5-tetranor-8-iso PGF2α.2 2,3-dinor-8-iso PGF2α is present in normal human urine at concentrations of 200-300 pg/ml.2 Its concentration is increased in conditions of oxidative injury (for example, smoking), and correlates well with that of the parent isoprostane, 8-iso PGF2α.2

1 Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

2 Chiabrando, C., Valagussa, A., Rivalta, C., et al. Identification and measurement of endogenous β-oxidation metabolites of 8-epi-prostaglandin F2a. J Biol Chem 274 1313-1319 (1999).

3 Roberts, L.J., Moore, K.P., Zackert, W.E., et al. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2α in humans. J Biol Chem 271 20617-20620 (1996).

Synonyms
  • 2,3-dinor-iPF2α-III
  • 2,3-dinor-8-iso PGF2α
Formal Name 9α,​11α,​15S-​trihydroxy-​2,​3-​dinor-​(8β)-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 221664-05-7
Molecular Formula C18H30O5
Formula Weight 326.4
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@@H]​(C/C=C\CC(O)​=O)​[C@@H]​(/C=C/[C@H]​(O)​CCCCC)​[C@H]​(O)​C1

Background Reading

Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

Roberts, L.J., Moore, K.P., Zackert, W.E., et al. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2α in humans. J Biol Chem 271 20617-20620 (1996).

Chiabrando, C., Valagussa, A., Rivalta, C., et al. Identification and measurement of endogenous β-oxidation metabolites of 8-epi-prostaglandin F2a. J Biol Chem 274 1313-1319 (1999).

2,3-dinor-8-iso Prostaglandin F2α is available in the following screening libraries:

Size Price Quantity Subtotal
25 µg $61.00 $0.00
50 µg $116.00 $0.00
100 µg $220.00 $0.00
1 mg $1,708.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-09. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

8-iso Prostaglandin F1α
8-iso Prostaglandin F2α
Prostaglandin F2α

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