Cayman Chemical | 8-iso-15-keto Prostaglandin F2α | Description • 8-iso-15-keto PGF2α; 8-epi-15-keto PGF2α

16390 8-iso-15-keto Prostaglandin F_2α

8-iso-15-keto PGF_2α; 8-epi-15-keto PGF_2α

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• See more Isoprostanes; Prostaglandins; Oxidative Injury

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8-iso-15-keto Prostaglandin F_2α (8-iso-15-keto PGF_2α) is a metabolite of the isoprostane 8-iso PGF_2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF_2α) is a prostaglandin-like product of non-specific lipid peroxidation.¹ In both humans and monkeys, exogenously infused 8-iso PGF_2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.² A similar pattern is observed when tritiated 8-iso PGF_2α is infused into rabbits.³ Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF_2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF_2α. 8-iso -15-keto PGF_2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.⁴

1 Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

2 Chiabrando, C., Valagussa, A., Rivalta, C., et al. Identification and measurement of endogenous β-oxidation metabolites of 8-epi-prostaglandin F2a. J Biol Chem 274 1313-1319 (1999).

3 Basu, S. Metabolism of 8-iso-prostaglandin F_2α FEBS Lett 428, 32-36 (1998).

4 Cracowski, J., Camus, L., Durand, T., et al. Response of rat thoracic aorta to F2-isoprostane metabolites. J Cardiovasc Pharmacol 39 396-403 (2002).

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Pricing updated 2010-03-20.
Prices are subject to change without notice.

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·	8-iso-15-keto Prostaglandin F2α
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