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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

U-46619

Cayman Chemical Item Number 16450

9,11-dideoxy-9α,11α-methanoepoxy Prostaglandin F2α; 9,11-dideoxy-9α,11α-methanoepoxy PGF2α (CAS 56985-40-1)

U-46619 (CAS 56985-40-1)

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Description

U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist.1 It exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle.2,3 Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for aggregation are 82, 145, and 65 nM, respectively.4

1 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

2 Coleman, R.A., Humphrey, P.P.A., Kennedy, I., et al. Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br J Pharmacol 73 773-778 (1981).

3 Liel, N., Mais, D.E., and Halushka, P.V. Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. Prostaglandins 33 789-797 (1987).

4 Tymkewycz, P.M., Jones, R.L., Wilson, N.H., et al. Heterogeneity of thromboxane A2 (TP-) receptors: Evidence from antagonist but not agonist potency measurements. Br J Pharmacol 102 607-614 (1991).

Synonyms
  • 9,11-dideoxy-9α,11α-methanoepoxy Prostaglandin F2α
  • 9,11-dideoxy-9α,11α-methanoepoxy PGF2α
Formal Name 9,​11-​dideoxy-​9α,​11α-​methanoepoxy-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 56985-40-1
Molecular Formula C21H34O4
Formula Weight 350.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCC(O)​/C=C/[C@H]​1C2OCC(C2)​C1C/C=C\CCCC(=O)​O

Background Reading

Coleman, R.A., Humphrey, P.P.A., Kennedy, I., et al. Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. Br J Pharmacol 73 773-778 (1981).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

Tymkewycz, P.M., Jones, R.L., Wilson, N.H., et al. Heterogeneity of thromboxane A2 (TP-) receptors: Evidence from antagonist but not agonist potency measurements. Br J Pharmacol 102 607-614 (1991).

Liel, N., Mais, D.E., and Halushka, P.V. Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. Prostaglandins 33 789-797 (1987).

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U-46619 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $70.00 $0.00
5 mg $315.00 $0.00
10 mg $560.00 $0.00
50 mg $2,450.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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