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11β-Prostaglandin F_2α Ethanolamide

Cayman Chemical Item Number 16522

11β-PGF_2α-EA (CAS 714966-38-8)

11β-Prostaglandin F2α Ethanolamide (CAS 714966-38-8)

See more	Prostaglandins (517)

Description

11β-Prostaglandin F_2α ethanolamide (11β-PGF_2α-EA) is the theoretical hepatic metabolite of PGD₂-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.¹ AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs.^2,3 PGD₂-EA is formed in activated RAW 264.7 cells treated with AEA.³

1 Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2 Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E₂ ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

3 Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

Synonyms	11β-PGF2α-EA
Formal Name	N-(2-hydroxyethyl)-9α,11β,15S-trihydroxy-prosta-5Z,13E-dien-1-amide
CAS Number	714966-38-8
Molecular Formula	C₂₂H₃₉NO₅
Formula Weight	397.6
Formulation	A solution in ethanol
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OCCN([H])C(CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)[C@@H](O)C[C@@H]1O)=O

Background Reading

Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E₂ ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

Kozak, K.R., Rowlinson, S.W., and Marnett, L.J. Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. J Biol Chem 275 33744-33749 (2000).

11β-Prostaglandin F2α Ethanolamide is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$86.00		$0.00
5 mg	$387.00		$0.00
10 mg	$688.00		$0.00
50 mg	$3,010.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Prostaglandin F_2α

Prostaglandin F_2α Ethanolamide

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11β-Prostaglandin F2α Ethanolamide