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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

11β-13,14-dihydro-15-keto Prostaglandin F2α

Cayman Chemical Item Number 16540

11β-13,14-dihydro-15-keto PGF2α (CAS 107615-77-0)

11β-13,14-dihydro-15-keto Prostaglandin F2α (CAS 107615-77-0)

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Description

11β-13,14-dihydro-15-keto Prostaglandin F2α (11β-13,14-dihydro-15-keto PGF2α) is a metabolite of Prostaglandin D2 (PGD2) in the 15-hydroxy PGDH pathway.1,2 Infusion or inhalation of tritiated PGD2 in normal males results in the appearance of peak levels of both 11β-PGF2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF2α in the plasma within 10 minutes.1 Homogenates of human lung metabolize PGD2 first to 11β-PGF2α and then to 11β-15-keto-PGF2α in the presence of NAD+, but no 11β-13,14-dihydro-15-keto PGF2α.2 Guinea pig liver and kidney homogenates metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α, via 11β-PGF2α, in the presence of NAD+ and NADP+.2

1 Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. Biochim Biophys Acta 963 151-161 (1988).

2 Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways. Biochem Pharmacol 38(19) 3267-3271 (1989).

Synonyms
  • 11β-13,14-dihydro-15-keto PGF2α
Formal Name 9α,​11β-​dihydroxy-​15-​oxo-​prost-​5Z-​en-​1-​oic acid
CAS Number 107615-77-0
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCCC(=O)​CC[C@H]​1[C@@H]​(O)​CC(O)​C1C/C=C\CCCC(=O)​O

Background Reading

Robinson, C., Hardy, C.C., and Holgate, S.T. The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men. Biochim Biophys Acta 963 151-161 (1988).

Robinson, C., Herbert, C.A., Bedwell, S., et al. The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways. Biochem Pharmacol 38(19) 3267-3271 (1989).

11β-13,14-dihydro-15-keto Prostaglandin F2α is available in the following screening library:

Size Price Quantity Subtotal
50 µg $41.00 $0.00
100 µg $78.00 $0.00
500 µg $328.00 $0.00
5 mg $2,460.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

11β-Prostaglandin F2α
Prostaglandin F2α

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