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13,14-dihydro Prostaglandin F_2α

Cayman Chemical Item Number 16660

13,14-dihydro PGF_2α (CAS 27376-74-5)

13,14-dihydro Prostaglandin F2α (CAS 27376-74-5)

See more	Prostaglandins (517)

Description

13,14-dihydro PGF_2α is the analog of PGF_2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF_2α. The ED₅₀ for 13,14-dihydro PGF_2α as a luteolytic agent in hamsters is 1.5 µg/100 g.¹

1 Andersen, N.H., Imamoto, S., Subramanian, N., et al. Molecular basis for prostaglandin potency. III. Tests of the significance of the 'hairpin conformation' in biorecognition phenomena. Prostaglandins 22 841-856 (1981).

Synonyms	13,14-dihydro PGF2α
Formal Name	9α,11α,15S-trihydroxy-prost-5Z-en-1-oic acid
CAS Number	27376-74-5
Molecular Formula	C₂₀H₃₆O₅
Formula Weight	356.5
Formulation	A solution in methyl acetate
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)CC[C@H]1C(O)CC(O)C1C/C=C\CCCC(=O)O

Background Reading

Andersen, N.H., Imamoto, S., Subramanian, N., et al. Molecular basis for prostaglandin potency. III. Tests of the significance of the 'hairpin conformation' in biorecognition phenomena. Prostaglandins 22 841-856 (1981).

Sun, F.F., Armour, S.B., Bockstanz, V.R., et al. Studies on 15-hydroxyprostaglandin dehydrogenase from monkey lung. Adv Prostaglandin Thromboxane Res 1 163-169 (1976).

Westwick, J. The effect of pulmonary metabolites of prostaglandins E₁, E₂ and F_2α on ADP-induced aggregation of human and rabbit platelets. Br J Pharmacol 58 297P-298P (1976).

Andersen, N.H., and Leovey, E.M.K. Identification and quantitative determination of prostaglandins by high pressure liquid chromatography. Prostaglandins 6 361-374 (1974).

Hanasaki, K., Kishi, M., and Arita, H. Phorbol ester-induced expression of the common, low-affinity binding site for primary prostanoids in vascular smooth muscle cells. J Biol Chem 265 4871-4875 (1990).

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13,14-dihydro Prostaglandin F2α is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$35.00		$0.00
5 mg	$158.00		$0.00
10 mg	$280.00		$0.00
50 mg	$1,225.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Prostaglandin F_2β

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13,14-dihydro Prostaglandin F2α