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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Fluprostenol Exclusive

Cayman Chemical Item Number 16768

16-m-trifluoromethylphenoxy tetranor PGF2α (CAS 54276-17-4)

Fluprostenol (CAS 54276-17-4)

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Description

Fluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity.1,2 Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.1,2 It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 µg/kg to terminate pregnancy.3 It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10−11 M.4

1 Abramovitz, M., Boie, Y., Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem 269 2632-2636 (1994).

2 Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Lett 355 317-325 (1994).

3 Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α. Nature 250 330-331 (1974).

4 Serrero, G., and Lepak, N.M. Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem Biophys Res Commun 233 200-202 (1997).

Synonyms
  • 16-m-trifluoromethylphenoxy tetranor PGF2α
Formal Name 9α,​11α,​15R-​trihydroxy-​16-​(3-​(trifluoromethyl)phenoxy)-​17,​18,​19,​20-​tetranor-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 54276-17-4
Molecular Formula C23H29F3O6
Formula Weight 458.5
Formulation A solution in ethanol
Purity ≥95%
λmax 222, 280 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(=O)​CCC/C=C\CC1C(O)​CC(O)​[C@H]​1\C=C\C(O)​COc1cccc(c1)​C(F)​(F)​F

Fluprostenol is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
25 mg $805.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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