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Fluprostenol isopropyl ester

Cayman Chemical Item Number 16769

Flu-Ipr; Travoprost; 16-m-trifluoromethylphenoxy tetranor PGF2α isopropyl ester (CAS 157283-68-6)

Fluprostenol isopropyl ester (CAS 157283-68-6)

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Description

Travoprost is the Alcon trade name for fluprostenol isopropyl ester, an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1,2 Travoprost is the active ingredient in Alcon’s Travatan brand ophthalmic solution. Fluprostenol isopropyl ester is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid.3 The free acid, fluprostenol, is a potent FP receptor agonist.4 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

1 Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

2 Hellberg, M.R., Sallee, V.L., Mclaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther 17(5) 421-432 (2001).

3 Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

4 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

Synonyms
  • Flu-Ipr
  • Travoprost
  • 16-m-trifluoromethylphenoxy tetranor PGF2α isopropyl ester
Formal Name 9α,​11α,​15R-​trihydroxy-​16-​(3-​(trifluoromethyl)phenoxy)-​17,​18,​19,​20-​tetranor-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ isopropyl ester
CAS Number 157283-68-6
Molecular Formula C26H35F3O6
Formula Weight 500.6
Formulation A solution in ethanol
Purity ≥98%
λmax 222, 280 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​(C[C@H]​([C@@H]​1/C=C/[C@@H]​(O)​COC2=CC=CC(C(F)​(F)​F)​=C2)​O)​[C@@H]​1C/C=C\CCCC(OC(C)​C)​=O

Background Reading

Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

Hellberg, M.R., Sallee, V.L., Mclaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther 17(5) 421-432 (2001).

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Fluprostenol isopropyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
50 mg $1,785.00 $0.00
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Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Looking for cGMP Travoprost? GMP API

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