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17-phenyl trinor Prostaglandin F_2α Exclusive

Cayman Chemical Item Number 16810

17-phenyl trinor PGF_2α; Bimatoprost (free acid) (CAS 38344-08-0)

17-phenyl trinor Prostaglandin F2α (CAS 38344-08-0)

See more	Prostaglandins (513) Ophthalmology (61)

Description

17-phenyl trinor Prostaglandin F_2α (17-phenyl trinor PGF_2α) is a metabolically stable analog of PGF_2α and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF_2α.¹ At the rat recombinant FP receptor expressed in CHO cells bimatoprost inhibits PGF_2α binding with a K_i of 1.1 nM.² The isopropyl ester of 17-phenyl trinor PGF_2α ethyl amide is slightly better than PGF_2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.³

1 Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F_2α receptor. Biochem Pharmacol 38 2375-2381 (1989).

2 Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F_2α receptors and the expression of the rat prostaglandin F_2α receptor. FEBS Lett 355 317-325 (1994).

3 Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Synonyms	17-phenyl trinor PGF2α Bimatoprost (free acid)
Formal Name	9α,11α,15S-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid
CAS Number	38344-08-0
Molecular Formula	C₂₃H₃₂O₅
Formula Weight	388.5
Formulation	A crystalline solid
Purity	>98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC(=O)CCC/C=C\CC1C(O)CC(O)[C@@H]1\C=C\C(O)CCc1ccccc1

Background Reading

Miller, W.L., Weeks, J.R., Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9 9-18 (1975).

Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Lake, S., Gullberg, H., Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F_2α receptors and the expression of the rat prostaglandin F_2α receptor. FEBS Lett 355 317-325 (1994).

Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F_2α receptor. Biochem Pharmacol 38 2375-2381 (1989).

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17-phenyl trinor Prostaglandin F2α is available in the following screening library:

Prostaglandin Screening Library I (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$46.00		$0.00
5 mg	$207.00		$0.00
10 mg	$368.00		$0.00
25 mg	$805.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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17-phenyl trinor Prostaglandin F2α Exclusive