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Lisinopril

Cayman Chemical Item Number 16833

MK 522; MK 521 (CAS 76547-98-3)

Lisinopril (CAS 76547-98-3)

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Description

Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes.1 Lisinopril is a potent ACE inhibitor that blocks the formation of angiotensin I with an IC50 value of 1.2 nM (ovine) and displays ID50 values of 2.3 and 6.5 µg/kg in rat and canine, respectively.2 At 0.1 nM lisinopril reduces the formation of endothelin-1 and increases nitric oxide in human vascular endothelial cells.3

1 Zaman, M.A., Oparil, S., and Calhoun, D.A. Drugs targeting the renin-angiotensin-aldosterone system. Nat Rev Drug Discov 1 621-636 (2002).

2 Patchett, A.A., Harris, E., Tristram, E.W., et al. A new class of angiotensin-converting enzyme inhibitors. Nature 288 280-283 (1980).

3 Desideri, G., Grassi, D., Croce, G., et al. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: Evidence of an oxidant-sensitive pathway. Mediators Inflamm (2008).

Synonyms
  • MK 522
  • MK 521
Formal Name N2-​[(1S)-​1-​carboxy-​3-​phenylpropyl]-​L-​lysyl-​L-​proline
CAS Number 76547-98-3
Molecular Formula C21H31N3O5
Formula Weight 405.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NCCCCC(N[C@@H]​(CCc1ccccc1)​C(=O)​O)​C(=O)​N1CCC[C@H]​1C(=O)​O

Background Reading

Desideri, G., Grassi, D., Croce, G., et al. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: Evidence of an oxidant-sensitive pathway. Mediators Inflamm (2008).

Zaman, M.A., Oparil, S., and Calhoun, D.A. Drugs targeting the renin-angiotensin-aldosterone system. Nat Rev Drug Discov 1 621-636 (2002).

Patchett, A.A., Harris, E., Tristram, E.W., et al. A new class of angiotensin-converting enzyme inhibitors. Nature 288 280-283 (1980).
Size Price Quantity Subtotal
100 mg $7.00 $0.00
500 mg $32.00 $0.00
1 g $56.00 $0.00
5 g $245.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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