Hexadecanal-d₅ contains five deuterium atoms at the 15, 15’, 16, 16 and 16 positions. It is intended for use as an internal standard for the quantification of hexadecanal by GC- or LC-mass spectrometry. Sphingosine-1-phosphate (S1P) is a potent bioactive phospholipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.¹ Hexadecanal is the 16-carbon aldehyde analog of palmitic acid. It is produced from the irreversible cleavage of S1P by S1P lyase 1 and is a major component of plasmalogen.^2,3

1 Leclercq, T.M., and Pitson, S.M. Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. IUBMB Life 58 467-472 (2006).

2 Reiss, U., Oskouian, B., Zhou, J., et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem 279(2) 1281-1290 (2004).

3 Pyne, S., and Pyne, N.J. Sphingosine 1-phosphate signalling in mammalian cells. Biochem J 349 385-402 (2000).

Leclercq, T.M., and Pitson, S.M. Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. IUBMB Life 58 467-472 (2006).

Reiss, U., Oskouian, B., Zhou, J., et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem 279(2) 1281-1290 (2004).

Pyne, S., and Pyne, N.J. Sphingosine 1-phosphate signalling in mammalian cells. Biochem J 349 385-402 (2000).