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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

CAY10581 Exclusive

Cayman Chemical Item Number 16838

(CAS 1018340-07-2)

CAY10581 (CAS 1018340-07-2)

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Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency.1 Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice.1 CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM).1 It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.1

1 Kumar, S., Malachowski, W.P., DuHadaway, J.B., et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem 51 1706-1718 (2008).

Formal Name (±)3,​4-​dihydro-​3-​hydroxy-​2,​2-​dimethyl-​4-​[(phenylmethyl)amino]-​2H-​naphtho[2,​3-​b]pyran-​5,​10-​dione
CAS Number 1018340-07-2
Molecular Formula C22H21NO4
Formula Weight 363.4
Formulation A crystalline solid
Purity ≥97%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1C2=C([C@H]​(NCC3=CC=CC=C3)​[C@H]​(O)​C(C)​(C)​O2)​C(C4=C1C=CC=C4)​=O

Background Reading

Kumar, S., Malachowski, W.P., DuHadaway, J.B., et al. Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem 51 1706-1718 (2008).
Size Price Quantity Subtotal
1 mg $29.00 $0.00
5 mg $131.00 $0.00
10 mg $232.00 $0.00
25 mg $508.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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