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Prostaglandin F3α Exclusive

Cayman Chemical Item Number 16990

PGF3α (CAS 745-64-2)

Prostaglandin F3α (CAS 745-64-2)

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Description

PGF3α is a COX product of EPA. The biosynthesis of PGF3α from EPA was demonstrated in vitro in human and rabbit ocular tissues.1 It has only 25% affinity at the ovine luteal FP receptor compared to PGF2α.2

1 Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31 1159-1164 (1986).

2 Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem Pharmacol 38 2375-2381 (1989).

Synonyms
  • PGF3α
Formal Name 9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E,​17Z-​trien-​1-​oic acid
CAS Number 745-64-2
Molecular Formula C20H32O5
Formula Weight 352.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@H]​(C/C=C\CCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​C/C=C\CC)​[C@H]​(O)​C1

Background Reading

Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. J Ocul Pharmacol 3 349-356 (1987).

Kulkarni, P.S., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in human and rabbit anterior uvea. Prostaglandins 31 1159-1164 (1986).

Balapure, A.K., Rexroad, C.E., Kawada, K., et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor. Biochem Pharmacol 38 2375-2381 (1989).

Prostaglandin F3α is available in the following screening library:

Size Price Quantity Subtotal
50 µg $36.00 $0.00
100 µg $68.00 $0.00
500 µg $288.00 $0.00
1 mg $504.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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