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Prostaglandin G2

Cayman Chemical Item Number 17010

PGG2 (CAS 51982-36-6)

Prostaglandin G2 (CAS 51982-36-6)

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Description

Prostaglandin G2 (PGG2) is the first intermediate in the COX pathway which is stable enough to be isolated and characterized.1 It is the C-15 hydroperoxide of PGH2. Under normal conditions, PGG2 is quickly metabolized by the peroxidase activity intrinsic to both COX-1 and -2 to give PGH2, which serves as the key precursor to the 2-series PGs and thromboxanes.1,2

1 Hamberg, M., Svensson, J., and Samuelsson, B. Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc Natl Acad Sci USA 71 3824-3828 (1974).

2 Kulmacz, R.J. Prostaglandin G2 levels during reaction of prostaglandin H synthase with arachidonic acid. Prostaglandins 34 225-240 (1987).

Synonyms
  • PGG2
Formal Name 9α,​11α-​epidioxy-​15S-​hydroperoxy-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 51982-36-6
Molecular Formula C20H32O6
Formula Weight 368.5
Formulation A solution in acetone
Purity >95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@@H]​(OO)​/C=C/[C@H]​1[C@@H]​2OO[C@@H]​(C2)​[C@H]​1C/C=C\CCCC(O)​=O

Background Reading

Eling, T.E., Glasgow, W.C., Curtis, J.F., et al. Studies on the reduction of endogenously generated prostaglandin G2 by prostaglandin H synthase. J Biol Chem 266 12348-12355 (1991).

Hamberg, M., Svensson, J., and Samuelsson, B. Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc Natl Acad Sci USA 71 3824-3828 (1974).

Kulmacz, R.J. Prostaglandin G2 levels during reaction of prostaglandin H synthase with arachidonic acid. Prostaglandins 34 225-240 (1987).

Prostaglandin G2 is available in the following screening library:

Size Price Quantity Subtotal
25 µg $72.00 $0.00
50 µg $137.00 $0.00
100 µg $259.00 $0.00
500 µg $1,152.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Arachidonic Acid
COX-1 (ovine)
COX-2 (ovine)
Prostaglandin H2
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