Prostaglandin H1 (PGH1) is a COX metabolite of DGLA and is the precursor to all 1-series PGs and thromboxanes. PGH1 is a suicide inhibitor of platelet thromboxane synthase with a Ki of 28 µM.1
1
Jones, D.A., and Fitzpatrick, F.A. “Suicide” inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets.. J Biol Chem26520166-20171(1990).
Jones, D.A., and Fitzpatrick, F.A. “Suicide” inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets.. J Biol Chem26520166-20171(1990).
Prostaglandin H1 is available in the following screening
library: