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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Prostaglandin H2

Cayman Chemical Item Number 17020

PGH2 (CAS 42935-17-1)

Prostaglandin H2 (CAS 42935-17-1)

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Description

Prostaglandin H2 (PGH2) was first isolated from incubations of arachidonic acid with ovine seminal vesicle microsomes, and was described as a potent vasoconstrictor.1 PGH2 is the precursor for all 2-series PGs and thromboxanes (TXs),2 and is a TP receptor agonist which irreversibly aggregates human platelets at 50-100 ng/ml. PGH2 is a suicide substrate for platelet TX synthase possessing a Ki of 18 µM as compared to 28 µM for PGH1.3

1 Hamberg, M., Svensson, J., Wakabayashi, T., et al. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc Natl Acad Sci USA 71 345-349 (1974).

2 Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu Rev Biochem 47 997-1029 (1978).

3 Jones, D.A., and Fitzpatrick, F.A. “Suicide” inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets.. J Biol Chem 265 20166-20171 (1990).

Synonyms
  • PGH2
Formal Name 9α,​11α-​epidioxy-​15S-​hydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 42935-17-1
Molecular Formula C20H32O5
Formula Weight 352.5
Formulation A solution in acetone
Purity >95%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@@H]​(O)​/C=C/[C@H]​1[C@@H]​2OO[C@@H]​(C2)​[C@H]​1C/C=C\CCCC(O)​=O

Background Reading

Jones, D.A., and Fitzpatrick, F.A. “Suicide” inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets.. J Biol Chem 265 20166-20171 (1990).

Samuelsson, B., Goldyne, M., Granström, E., et al. Prostaglandins and thromboxanes. Annu Rev Biochem 47 997-1029 (1978).

Hamberg, M., Svensson, J., Wakabayashi, T., et al. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc Natl Acad Sci USA 71 345-349 (1974).

Prostaglandin H2 is available in the following screening library:

Size Price Quantity Subtotal
25 µg $27.00 $0.00
50 µg $51.00 $0.00
100 µg $97.00 $0.00
500 µg $432.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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U-51605
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