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6α-Prostaglandin I₁

Cayman Chemical Item Number 18110

5,6α-dihydro PGI₂; 6α-PGI₁ (CAS 62777-90-6)

6α-Prostaglandin I1 (CAS 62777-90-6)

See more	Prostaglandins (513)

Description

6α-Prostaglandin I₁ (6α-PGI₁) is a stable Prostaglandin I₂ (PGI₂) analog resistant to hydrolysis in aqueous solutions. 6α-PGI₁ promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI₂ in eliciting the response.¹ 6α-PGI₁ exhibits an IC₅₀ of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI₂ (0.4 ng/ml).²

1 Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue. Prostaglandins 22(1) 105-115 (1981).

2 Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders. Adv Exp Med Biol 164 193-209 (1984).

Synonyms	5,6α-dihydro PGI2 6α-PGI1
Formal Name	6R,9α-epoxy-11α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number	62777-90-6
Molecular Formula	C₂₀H₃₄O₅
Formula Weight	354.5
Formulation	A crystalline solid
Purity	>99%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)/C=C/[C@H]1C(O)CC2O[C@H](CCCCC(=O)O)CC12

Background Reading

Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue. Prostaglandins 22(1) 105-115 (1981).

Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders. Adv Exp Med Biol 164 193-209 (1984).

6α-Prostaglandin I1 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$46.00		$0.00
5 mg	$207.00		$0.00
10 mg	$368.00		$0.00
50 mg	$1,610.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Related Products

6β-Prostaglandin I₁

Prostaglandin I₂ (sodium salt)

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6α-Prostaglandin I1