Cayman Chemical | 6β-Prostaglandin I1 | Description • 5,6β-dihydro PGI2; 6β-PGI1 (CAS 62770-50-7)

18120 6β-Prostaglandin I₁

5,6β-dihydro PGI₂; 6β-PGI₁ (CAS 62770-50-7)

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6β-PGI₁ is a stable PGI₂ analog resistant to hydrolysis in aqueous solutions. 6β-PGI₁ has a much longer half-life than PGI₂, but a greatly reduced molar potency for receptor mediated function. 6β-PGI₁ has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI₂. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI₂.^1,2

1 Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

2 Blair, I.A., Hensby, C.N., MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. Br J Pharmacol 69 519-525 (1980).

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Pricing updated 2010-03-20.
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