Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

6β-Prostaglandin I₁

Cayman Chemical Item Number 18120

5,6β-dihydro PGI₂; 6β-PGI₁ (CAS 62770-50-7)

6β-Prostaglandin I1 (CAS 62770-50-7)

See more	Prostaglandins (513)

Description

6β-PGI₁ is a stable PGI₂ analog resistant to hydrolysis in aqueous solutions. 6β-PGI₁ has a much longer half-life than PGI₂, but a greatly reduced molar potency for receptor mediated function. 6β-PGI₁ has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI₂. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI₂.^1,2

1 Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

2 Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. Br J Pharmacol 69 519-525 (1980).

Synonyms	5,6β-dihydro PGI2 6β-PGI1
Formal Name	6S,9α-epoxy-11α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number	62770-50-7
Molecular Formula	C₂₀H₃₄O₅
Formula Weight	354.5
Formulation	A crystalline solid
Purity	>99%
Stability	2 years
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)/C=C/[C@H]1C(O)CC2O[C@H](CCCCC(=O)O)CC12

Background Reading

Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. Br J Pharmacol 69 519-525 (1980).

6β-Prostaglandin I1 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$46.00		$0.00
5 mg	$207.00		$0.00
10 mg	$368.00		$0.00
50 mg	$1,610.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

6α-Prostaglandin I₁

Prostaglandin I₂ (sodium salt)

Downloads

	Download Product Insert 155 Kb PDF
	Download Material Safety Data Sheet (MSDS) 119 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

6β-Prostaglandin I1