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5-cis Carbaprostacyclin

Cayman Chemical Item Number 18211

(5Z)-6a-Carbaprostaglandin I₂ (CAS 69609-77-4)

5-cis Carbaprostacyclin (CAS 69609-77-4)

See more	Receptor Biochemistry (344) Prostaglandins (517) Receptor Agonist (161)

Description

5-cis Carbaprostacyclin is a stable analog of PGI₂ and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC₅₀ of 2.8 µM compared to 0.3 µM for carbaprostacyclin.^1,2 5-cis Carbaprostacyclin is a much weaker effector of rabbit mesenteric artery relaxation with an EC₅₀ of 104 µM compared to 5.9 µM for carbaprostacyclin. It even antagonizes the adenylate cyclase activation induced by carbaprostacyclin.²

1 Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

2 Corsini, A., Folco, G.C., Fumagalli, R., et al. (5Z)-carbacyclin discriminates between prostacyclin-receptors coupled to adenylate cyclase in vascular smooth muscle and platelets. Br J Pharmacol 90 255-261 (1987).

Synonyms	(5Z)-6a-Carbaprostaglandin I2
Formal Name	6,9α-methylene-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number	69609-77-4
Molecular Formula	C₂₁H₃₄O₄
Formula Weight	350.5
Formulation	A crystalline solid
Purity	>99%
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCC(O)/C=C/[C@H]1C(O)CC2C\C(=C\CCCC(=O)O)\CC12

Background Reading

Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

Corsini, A., Folco, G.C., Fumagalli, R., et al. (5Z)-carbacyclin discriminates between prostacyclin-receptors coupled to adenylate cyclase in vascular smooth muscle and platelets. Br J Pharmacol 90 255-261 (1987).

5-cis Carbaprostacyclin is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$118.00		$0.00
5 mg	$531.00		$0.00
10 mg	$944.00		$0.00
50 mg	$4,130.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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