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Carbaprostacyclin-biotin

Cayman Chemical Item Number 18213

Carbacyclin-biotin; cPGI-biotin

Carbaprostacyclin-biotin

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Description

Carbaprostacyclin is a structural analog of prostacyclin (PGI2) with about 1/10 the receptor binding affinity of prostacyclin.1 Carbaprostacyclin is a relatively indiscriminant ligand for prostaglandin receptors, binding to all the recombinant human PG receptors, except the TP receptor, with an affinity which is a significant fraction of the natural ligand.2 Carbaprostacyclin-biotin is therefore a useful affinity ligand for the binding and purification of a number of different receptors subtypes.

1 Schrör, K., Darius, H., Matzky, R., et al. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK36374) - equipotent to PGI2 in vitro. Naunyn Schmiedebergs Arch Pharmacol 316 252-255 (1981).

2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

Synonyms
  • Carbacyclin-biotin
  • cPGI-biotin
Formal Name N-​6,​9α-​methylene-​11α,​15S-​dihydroxy-​prosta-​5E,​13E-​dien-​1-​oyl-​N'-​biotinoyl-​1,​5-​diaminopentane
Molecular Formula C36H60N4O5S
Formula Weight 661.0
Formulation A solution in ethanol
Purity >95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​C[C@@H]​2C/C(=C\CCCC(=O)​NCCCCCNC(=O)​CCCC[C@H]​3SC[C@@H]​4NC(=O)​N[C@H]​34)​/C[C@H]​12

Background Reading

Schrör, K., Darius, H., Matzky, R., et al. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK36374) - equipotent to PGI2 in vitro. Naunyn Schmiedebergs Arch Pharmacol 316 252-255 (1981).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).
Size Price Quantity Subtotal
100 µg $43.00 $0.00
500 µg $194.00 $0.00
1 mg $344.00 $0.00
5 mg $1,505.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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Carbaprostacyclin
Carbaprostacyclin methyl ester Exclusive
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